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. 2007 Jun 29;3(6):e92. doi: 10.1371/journal.ppat.0030092

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© 2007 Xu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) CaFT profiles of radicicol with genes encoding co-chaperones of Hsp90p highlighted, including SGT1 (orf19.4089), CDC37 (orf19.5531), CNS1 (orf19.6052), orf19.7602 (an ortholog of ScAHA1), and CPR6 (orf19.7654) ([30] and references therein). Radicicol also elicited HI of ERG27 (orf19.3240), CDR1 (orf19.6000, an efflux pump), and PRS1 (orf19.1575, involved in cell integrity/stress signaling as reported [32]).

(B) Spot tests of radicicol against heterozygous deletion strains corresponding to HSP90 and its co-chaperones.