TABLE 1.
Parameters of ERGs of Rp1-mycMice
| Rod-Driven b-Wave | Rod a-Wave | Cone-Driven b-Wave | |||
|---|---|---|---|---|---|
| Age/Genotype (n) | bmax,rod(μV) | I0.5(scot cd-s ∙ m–2) | amax(μV) | KAs–2(scot cd-s ∙ m–2)–1 | bmax,cone(μV) |
| 4–5 Weeks | |||||
| Rp1myc/myc(10) | 141 ± 64 | (2.1 ± 0.9) × 10–3 | 88 ± 45 | 1478 ± 690 | 81 ± 24 |
| Rp1+/myc(11) | 188 ± 60 | (1.4 ± 1.0) × 10–3 | 199 ± 54 | 1060 ± 390 | 130 ± 40 |
| Rp1+/+(10) | 251 ± 89 | (1.4 ± 0.8) × 10–3 | 233 ± 68 | 1700 ± 490 | 153 ± 66 |
| 4–8 Months | |||||
| Rp1myc/myc(10) | 109 ± 69 | (1.3 ± 0.6) × 10–3 | 36 ± 21 | 651 ± 250 | 49 ± 23 |
| Rp1+/myc(24) | 138 ± 55 | (1.5 ± 0.5) × 10–3 | 191 ± 64 | 1680 ± 600 | 89 ± 28 |
| Rp1+/+(24) | 203 ± 85 | (1.9 ± 0.6) × 10–3 | 233 ± 53 | 1700 ± 720 | 106 ± 24 |
The first column gives the age/genotype of the mice and the number of mice tested. The entries in each column are the mean ± SD of the parameter, measured for the group of animals identified in the first column. The parameters are as follows:bmax,rodis the saturating amplitude, and I0.5the intensity that produces a half-saturating amplitude, respectively, of the scotopic b-wave response, extracted as illustrated in Figs. 6A–C; amaxis the saturating amplitude of the a-wave, measured as illustrated in Figs. 6D–F; KAdescribes the efficacy of the activation steps of the rod transduction cascade (Methods, Figs. 6G–I); bmax,coneis the saturating amplitude of the cone-driven b-wave, obtained in the presence of a rod-saturating steady background.34