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. 2007 Jun 27;405(Pt 2):299–306. doi: 10.1042/BJ20070051

Figure 1. Constructs and mutants of the human proα1(V) chain.

Figure 1

(A) Schematic representation of the N-propeptide construct referred to as Nα1. It consists of NC3, COL2, NC2 and 11 triplets from COL1. (B) Sequences of the C-propeptide encompassing the furin cleavage site and of the R1584A/R1585A mutant. The two arginine residues at positions 1584 and 1585 were mutated to alanine. (C) Sequences of the N-propeptide encompassing the BMP-1 cleavage site and of the BMP-1 cleavage site mutants. COL, collagenous domain; NC, non-collagenous domain. Mutated residues are underlined. Arrows indicate cleavage sites.