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Increased production in common variable immunodeficiency (CVID) of IFN-γ in the CD28+ subset of CD8+ cells. After 16 h phorbol myristate acetate (PMA) and ionomycin with monensin, there was a significant increase (*P< 0.05) in the proportion of IFN-γ+ CD8+ cells from the CVID patients (•) compared with normal donors (○), but only within the CD28+ subset.
