Fig. 3.
Effect of repeated intracerebroventricular (icv) administration of annexin-1 (1–188) on clinical signs of EAE (experiment 1). EAE was induced by injecting guinea pig spinal cord (GSC) homogenate. Rats were given once daily icv injections (arrows) of annexin-1 (1–188) (2.15 μg in 5 μl in 2.5 min, n = 5) or saline (controls, 5 μl in 2.5 min, n = 5) at 8–12 days after the induction of EAE. Treatment with annexin-1 (1–188) reduced the clinical severity of EAE (P< 0.02, χ2 test) as well as duration of EAE (P< 0.04, Student's t-test).