Fig. 4.

Effect of repeated intracerebroventricular (icv) administration of annexin-1 (1–188) on body weight during EAE (experiment 1). The median of daily weight loss or weight gain per group is given in grams. EAE was induced by injecting guinea pig spinal cord (GSC) homogenate. Rats were given daily icv injections (arrows) of annexin-1 (1–188) (2.15 μg in 5 μl in 2.5 min, n = 5) or saline (controls, 5 μl in 2.5 min, n = 5) at 8–12 days after induction of EAE. Treatment with annexin-1 (1–188) reduced weight loss during clinical disease of EAE (P< 0.01 at day 11, P< 0.04 at day 12, and P< 0.05 at day 13 after induction of EAE, Mann–Whitney U-test).