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Effect of a single intracerebroventricular (icv) injection of polyclonal anti-annexin-1 (1–188) on EAE (experiment 2). EAE was induced by subcutaneous injection of guinea pig spinal cord (GSC) homogenate. Rats were treated once icv at day 9 (arrow) with polyclonal antibodies against annexin-1 (5 μl in 2.5 min, n = 6) or saline (controls, 5 μl in 2.5 min, n = 6).
