Fig. 1.

Mycobacterium tuberculosis growth and reactivation. Mice were infected with 10³ colony-forming units (CFU) of M. tuberculosis (Erdman) intranasally. Growth in the lung was monitored at the times indicated. Once a latent infection was established, the hypothalamic–pituitary–adrenal (HPA) axis was activated by restraining the mice for 10 15-h sessions. The growth of the Mycobacteria was monitored by plate count. The time represents weeks after initial infection. Values represent means ± s.e.m. of n = 4 individual groups of three mice. The effect of HPA activation and of time was significant as determined by anova. ▴, Control; •, HPA activation.