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Proliferation of a HTLV-1 gp21 sp378/sp382-specific CD4+ T cell line (BK/1C11) depending on concentration and amino acid sequences of peptides. (a) Response to two long overlapping synthetic peptides, sp378 and sp382, which were used for selection of T cell lines, and to recombinant HTLV-1 p21. (b) Epitope analysis using short overlapping synthetic peptides with one amino acid shift. Values are expressed as mean + s.d. of triplicated data per point.
