Fig. 2.

Epitopic relationship between mouse MoAbs [2] and recombinant human Fab [6] to the immunodominant region. Mouse MoAb binding to ¹²⁵I-thyroid peroxidase (TPO) was measured in the absence and presence of Fab SP1.4, WR1.7, TR1.8 or TR1.9 (each at 4 × 10⁻⁸ m). The percentage inhibition of radiolabelled TPO binding is represented by a bar with shading corresponding to that in the inset. Binding for the 12 MoAbs without Fab averaged 10.4 ± 4.4% (mean ± s.d.).