Fig. 5.

Epitopic relationship between recombinant human thyroid peroxidase (TPO)-specific Fab from different laboratories. ¹²⁵I-TPO binding by nine recombinant Fab recently cloned in the UK [14] was measured in the absence and presence of Fab SP1.4, WR1.7, TR1.8 or TR1.9 (each at 4 × 10⁻⁸ m). The percentage inhibition of radiolabelled TPO binding is represented by a bar with shading corresponding to that in the inset. In the absence of free competing Fab, average binding of the nine test Fab was 4.9 ± 1.5% (mean ± s.d.).