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Inhibition of the contact sensitivity (CS) reaction (a) and its passive transfer (b) by Sirolimus (SRL), FK506 and cyclosporin A (CsA). Positive control group refers to mice that were immunized (CS) or received 4 day trinitrochlorobenzene (TNCB)-immune lymph node cells (passive transfer) and were challenged with TNCB. Negative control refers to mice that were only challenged with TNCB (challenge only). *P < 0.001 compared with the positive control group.
