Fig. 3.

Effect of Sirolimus (SRL), FK506 and cyclosporin A (CsA) on the T cell subsets that mediate the contact sensitivity (CS) reaction. Four day trinitrochlorobenzene (TNCB)-immune lymph node cells from mice that had been treated with SRL, CsA or FK506 were injected into naive recipient mice together with αβ⁺, γδ⁺ or B220⁺ T lymphocytes that had been positively sorted from TNCB-immune lymph node cells. *P < 0.001 compared with the negative control group.