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Sirolimus (SRL) and FK506 inhibit both αβ and γδ T lymphocytes. Four day trinitrochlorobenzene (TNCB)-immune lymph node cells from mice that had been treated with SRL or FK506 were transferred into naive recipient mice together with combinations of two positively selected populations of αβ+, γδ+ or B220+ T lymphocytes. *P < 0.001 compared with the negative control group.
