Fig. 2.

Persons with Bloom's syndrome (BS) have normal V_H6 mutations. Nucleotide sequences of mutated V_H6 regions from peripheral blood lymphocytes of persons with BS, BS 1–3. Two independent bacterial colonies from subject BS 1 are labelled as 1a and 1b. As with V_H26, all clones were associated with IgG rearrangements, with CDR1 and CDR2 as shown. As with V_H26, sequences not attributed to V_H6 are not shown and were not analysed. Dashes indicate positions with sequence identity to the germ-line. No V_H6 clones were excluded. The sequences start 3′ of the 5′ V_H6 polymerase chain reaction (PCR) primer at amino acid 9. Genbank accession numbers for these sequences have been assigned: no. AF015136–46.