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Immunofluorescence studies on human gallbladder epithelial cells (HGBEC). (A) Primary sclerosing cholangitis (PSC) serum produces a fine granular cytoplasmic staining pattern on HGBEC. (B) Anti-catalase antibodies on HGBEC lead to a fine granular cytoplasmic staining pattern. (C) PSC serum after removing anti-catalase antibodies with affinity chromatography. The cytoplasmic staining pattern is reduced.
