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Schematic diagram illustrating the derivation of chimeric human α3(IV)/α1(IV)NC1 domains. Exchange of corresponding regions of α3(IV)NC1 and α1(IV)NC1 domains to create six chimeric α3(IV)/α1(IV)NC1 domains. The constructs are described according to the origins of their amino, central and carboxyl regions, i.e. α331 was derived from the amino and central regions of α3(IV)NC1 and the carboxyl region of α1(IV)NC1.
