Fig. 4.

Contact sensitivity (CS) induced by buccal immunization with 2,4-dinitrofluorobenzene (DNFB) is mediated by class I-restricted CD8⁺ effector T cells, independently of CD4⁺ T cells. (a) Heterozygote β2m⁺/° (•) or homozygote β2m°/° (○) mice and (b) heterozygote Aβ⁺/° (▪) or homozygote Aβ°/° (□) mice were buccally sensitized with 0.5% of DNFB and ear-challenged 5 days later with 0.2% DNFB. Ear swelling, expressed as mean ± s.d. of six mice per group, was determined at various time points after challenge. The data shown are representative of two to three experiments.