Figure 3.
Inhibition of IgG-mediated passive cutaneous anaphylaxis (PCA) by the blocking of FcγR function in CD40-deficient mice. The purified IgG fraction of anti-ovalbumin (OVA) serum was injected into CD40-deficient mice intradermally with or without 2.4G2 MoAb. Standard murine IgG was used as control. Similar results were confirmed in four independent experiments. Upper right, anti-OVA IgG with 2.4G2; upper left, anti-OVA IgG alone; lower right, standard murine IgG with 2.4G2; lower left, standard murine IgG alone.