Fig. 4.

Progressive increase in peptide-specific cytolytic activity in CD8 T cell lines. Data are shown for two representative prostate-specific antigen (PSA) 68–77 (a) and prostate-specific membrane antigen (PSM) 557–566 (b) CD8 T cell lines. Ovalbumin 258–276 was used as a negative control. In addition, HLA-DR4-restricted peptides were also used as negative controls in these assays, the results were identical with the data obtained with ovalbumin 258–276 (data not shown). The data are expressed as percentage specific cytotoxicity as described for Fig. 3.