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Changes of IL-12 and IL-13 before disease flare in seven patients. The levels of IL-12 in three patients (cases 1–3) increased gradually before the disease flare (a), and those in other patients increased long before flare and decreased prior to flare (b). Although three patients (cases 1, 4 and 6) showed an increase in the level of IL-13, the different change to IL-12 was also shown (cases 2, 4 and 5).
