Fig. 3.

Role of CD40 ligand and IFN-γ in lymphocytic choriomeningitis virus (LCMV)-induced increase in sTNF-R75 levels in serum (a), as well as in production of TNF-α and nitric oxide (NO) by splenic adherent cells in vitro (b). LCMV-infected (inf.) CD40 ligand-deficient (CD40L−/−) mice, CD40L+/− female mice, IFN-γ-deficient (IFN-γ −/−) mice and wild-type (+/+) mice were killed and tested 8 days post-infection, together with uninfected control mice (con.) from both groups. Points represent individual mice, and bars are means ± s.e.m. of groups.