Table 5.

IL-12/IL-10 and activity of inflammation

Secretion of IL-12 and IL-10 (median cytokine values in pg/mg protein (and interquartile range)) in antrum biopsy cultures in Helicobacter pylori-infected and non-infected patients with different activity of gastritis (polymorphonuclear (PMN) cell infiltration). Secretion of IL-12 was significantly associated with inflammatory activity in H. pylori-associated gastritis in contrast to H. pylori-negative gastritis (matched samples for mild activity, P < 0.0001; matched samples for moderate activity, P = 0.0004). Differences were also observed for IL-10 (mild activity, P = 0.04; moderate activity, P = 0.03). Significance for comparison against specimens without inflammatory changes: *P < 0.0001; **P = 0.0001; †P = 0.0002; ††P = 0.01.