Fig. 7.

Anti-CD40 MoAb significantly increases B7.2⁺B7.1⁻ and decreases B7.2⁻B7.1⁺ B cells in culture with cyclosporin A (CsA) or dexamethasone. Peripheral blood mononuclear cells (PBMC) were cultured for 48 h with 100 ng/ml toxic shock syndrome toxin-1 (TSST-1) in the presence or absence of 1 μg/ml CsA or 10⁻⁶m dexamethasone. Anti-CD40 MoAb at 1 μg/ml was added to activate CD40 molecule on B cells. These experiments demonstrate that anti-CD40 MoAb significantly reversed the effect of CsA and dexamethasone on B7.2⁺B7.1⁻ and B7.2⁻B7.1⁺ B cells in the presence of TSST-1. Results from individuals and geometric mean values are shown.