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Nasal administration of IL-4 suppresses EAE in Lewis rats. Four groups of rats (n = 5 in each group) received IL-4 at amounts of 0, 10 ng, 100 ng, and 1000 ng daily for 5 consecutive days before EAE induction. Two independent experiments revealed similar results. ○, PBS; □, IL-4 50 ng; •, IL-4 500 ng; ▪, IL-4 5000 ng.
