Fig. 2.

Effect of anti-IL-4R MoAb on IL-4 production by human neonatal naive CD4⁺ T cells. Resting CD4⁺CD45RO⁻ cord blood T cells (5 × 10⁵/ml) were cultured with P815/CD80 cells (5 × 10⁵/ml) in the presence or absence of anti-IL-4R MoAb (2.5 μg/ml). Anti-CD3 MoAb (UCHT1) was added at a concentration of 2 μg/ml. Supernatants were collected after 72 h of culture and the IL-4 concentrations in the supernatants were determined by ELISA. The results (mean ± s.e.m.) of seven independent experiments are shown. **P < 0.01.