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Dose-dependent suppression of MLD-SZ-induced hyperglycaemia in mice treated with A77 1726. Plasma glucose levels in mice (n = 6 in each group) receiving, respectively, MLD-SZ (40 mg/kg per day, for 5 consecutive days) in conjunction with 10 daily i.p. injections of saline only (•), or different doses of A77 1726: 5 mg/kg (▪), 10 mg/kg (○), or 20 mg/kg (▴). Significantly different from the value of MLD-SZ-treated but non-A77 1726-treated control mice: *P ≤ 0.01; Student's t-test.
