Fig. 2.

Preventive effect of i.p. injection of anti-CD86 MoAb. Anti-CD80 MoAb (100 μg) (n = 8), and anti-CD86 (n = 8) were injected intraperitoneally into 3d-thymectomized (Tx) NFS/sld mice once a week (treated with MoAb from 3–7 weeks). These groups were compared with controls treated with PBS alone (n = 7). Mice with treatment were examined histopathologically at 8 weeks. Mean grade of inflammatory lesions was expressed as described in Materials and Methods. *P < 0.01, Mann–Whitney U-test.