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Lymphocytes of healthy individuals treated with hypoxanthine (HX)/xanthine oxidase (XO) (1.0 mm/10 mU/ml),HX and XO alone (left). Dose-dependent effect of catalase (▪) and superoxide dismutase (SOD; •) on cells treated with HX (1.0 mm) and XO (10 mU) for 24 h (right). One hundred percent means 1000 U catalase and 10 000 U SOD. Mean values ± s.d. of (a) 7-aminoactinomycin D (7AAD) incorporation (n = 8) and (b) number of Bcl-2-expressing cells (n = 4) detected by flow cytometry.
