Fig. 1.
TM-β1 improves the survival of human cells in the peritoneal cavity of NOD-SCID mice when compared with SCID mice treated in the same way. SCID and NOD-SCID mice were pretreated or not 24 h before i.p. reconstitution with 5 × 106 Hu-PBL. One group of NOD-SCID mice was pretreated with TM-β1 and irradiated with 3 Gy (\object(90%,90%)="og1"). The survival of the human total (CD45+) and T (CD3+) cell populations was evaluated 7 and 14 days later by FACS analysis. Bars represent the mean values (± s.e.m.) of the absolute cell numbers recovered from the peritoneum of three mice. *P < 0.05 versus SCID; **P < 0.05 versus SCID and NOD-SCID; ***P < 0.05 versus SCID, NOD-SCID and SCID-TM-β1 mice.