Table 2.

TM-β1 pretreatment enhances human IgG and IgM production in Hu-PBL-SCID and NOD-SCID mice

Mice were pretreated with TM-β1 or were left untreated. One group of NOD-SCID mice was pretreated with TM-β1 and irradiated with 3 Gy (). Twenty-four hours later, 5 × 10⁶ Hu-PBL were injected intraperitoneally. Human immunoglobulin concentrations were determined by ELISA in mouse plasma obtained 2 weeks after the Hu-PBL transfer.

*P < 0.05 versus SCID mice; **P < 0.05 versus SCID and NOD-SCID; ***P < 0.05 versus SCID, NOD-SCID and SCID-TM-β1 mice; ****P < 0.05 versus all other groups; †P < 0.05 versus NOD-SCID-TM-β1.