Fig. 1.

Protocol to investigate the effect of variable iodide intake on AKR/N mice that were untreated or injected on six occasions at 2-weekly intervals with viable, mitomycin C-treated TPO⁺ class II⁺ RT4.15HP fibroblasts. Lo I, Low iodide chow (see Materials and Methods) for 10 days plus 0.1% methimazole in drinking water; low iodide chow plus normal water for 2 days; Hi I, normal chow plus 0.05% potassium iodide in the drinking water for 2 days.