Fig. 3.

The effect of intravenous sCR1 on the development of collagen-induced arthritis (CIA) as assessed by clinical score (a), change in paw diameter (b) and change in paw volume (c). Treated animals (▪) (n = 5) were given i.v. sCR1 every 12 h for 5 consecutive days starting on day 7 in order to maintain complete complement inhibition. Control animals (•) (n = 5) received a twice daily injection of i.v. saline. The period of complement inhibition is represented by the solid bar. ***Statistically significant difference between the control and treated groups, P < 0.002; **statistically significant difference between the control and treated groups, P < 0.02; *statistically significant difference between the control and treated groups, P < 0.05.