Fig. 5.

The effect of sCR1 on established collagen-induced arthritis (CIA) as assessed by clinical score (a), change in paw diameter (b) and change in paw volume (c). On day 14, arthritic animals were divided into two equal groups matched for clinical score. Treated animals (▪) received intravenous sCR1 every 12 h for 5 consecutive days from day 14 to day 18. The period of complement inhibition is represented by the solid black bar. Control animals (•) received a twice daily intravenous dose of saline for 5 consecutive days from day 14 and remained complement-sufficient throughout. *Statistically significant difference between the treated and untreated groups, P < 0.05.