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. 2000 Jun;120(3):424–433. doi: 10.1046/j.1365-2249.2000.01255.x

Table 2.

Influence of age on the frequencies of endocrine cells and myenteric nerves in the colon of healthy IL-2+/+ and IL-2+/– mice

Changes caused by increasing age

Numbers of endocrine cells expressing Densities of myenteric nerves expressing


PYY Glucagon Serotonin PGP 9.5 SP VIP
IL-2+/+ Increased Increased Increased Unchanged Unchanged Increased
n = 16 rs = 0·59 rs = 0·51 rs = 0·57 rs = 0·47 rs = 0·23 rs = 0·65
(3 F, 13 M) P = 0·02 P = 0·04 P = 0·02 P = 0·006
IL-2+/– Unchanged Unchanged Unchanged Unchanged Unchanged Unchanged
n = 13 rs = − 0·11 rs = 0·02 rs = 0·02 rs = 0·27 rs = 0·23 rs = 0·34
(1 F, 12 M)

PYY, Polypeptide YY; PGP 9.5, protein gene product 9.5; SP, substance P; VIP, vasoactive intestinal polypeptide; n, number of mice/group; F, female; M, male; rs, correlation coefficient as determined by Spearman rank correlation test; P, probability that the observed correlation is due to chance alone; unchanged, no significant correlation with age and P > 0·05.