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(a) Time course of synovium index, established by grading each knee synovial membrane from 1 to 4 depending on size and aspect. Each point represents the mean value +s.e.m. of five rats. (b) Time course of arthritic index, established by scoring each paw from 0 to 4 based on levels of swelling and periarticular erythema. Each point represents the mean value +s.e.m. of five rats.
