Table 1.

Effects of TXA₂ receptor antagonists, protein kinase C (PKC) inhibitors, or inhibitors of transcription factors on cellular viability of human vascular endothelial cells

	Cell viability (%)
	6 h after treatment	24 h after treatment
SQ29 548, 10−5m	104·6 ± 2·6	102·5 ± 0·7
BAYu3405, 10−5m	100·4 ± 2·0	108·5 ± 1·6
Staurosporine 3 nm	102·9 ± 1·6	95·1 ± 3·2
GF 109203X 5 μm	104·2 ± 2·0	96·2 ± 1·2
3-AB 1 mm	107·3 ± 1·2	102·5 ± 1·2
PDTC 100 μm	102·4 ± 2·0	97·6 ± 1·6
NAC 30 mm	95·1 ± 5·0	94·1 ± 6·5

Human umbilical vein endothelial cells were treated with SQ29 548, BAYu3405, staurosporine, GF 109203X, 3-AB, PDTC, or NAC, in the concentrations indicated. Then the cells were incubated for 6 h or 24 h, followed by a 2-h treatment with 1·2 mm MTT and photometric determination of formazan dye concentration. Data represent means ±s.d. of three separate experiments as percentage of control.