Table 2.
Local challenge of oral mucosa with gliadin. The presence of T cell subsets in the oral mucosal epithelium of patients with treated coeliac disease and healthy controls. The results of solvent provocation without gliadin in patients with treated coeliac disease are also shown
| Cells/mm2; mean ±s.d. | |||||
|---|---|---|---|---|---|
| Epithelium | CD3+ | CD4+ | CD8+ | αβ+ | γδ+ |
| Coeliac disease patients, n = 37 | |||||
| Before challenge | 193·0 ± 76·1* | 76·1 ± 56·2 | 120·9 ± 93·7 | 114·5 ± 81·0**** | 3·7 ± 12·4 |
| Supramucosal challenge | 230·1 ± 162·0 | 162·9 ± 126·6** | 204·1 ± 127·7*** | 125·9 ± 117·3 | 43·7 ± 12·4 |
| with gliadin powder | |||||
| Submucosal challenge | 148·9 ± 85·8 | 90·0 ± 58·3 | 93·3 ± 69·2 | 81·4 ± 53·5 | 1·4 ± 4·2 |
| with gliadin solution | |||||
| Solvent provocation†, n = 12 | 88·0 ± 60·0 | 81·1 ± 71·4 | 95·3 ± 72·6 | 60·1 ± 50·7 | 0 |
| Healthy controls, n = 10 | |||||
| Before challenge | 86·3 ± 86·5 | 46·3 ± 40·3 | 83·8 ± 85·3 | 67·5 ± 61·4 | 1·3 ± 3·5 |
| Submucosal challenge | 80·0 ± 50·0 | 58·9 ± 39·1 | 57·8 ± 38·3 | 84·4 ± 50·8 | 4·0 ± 9·7 |
| with gliadin solution | |||||
Comparison of values in epithelium After a Bonferroni correction
CD patients:
*
versus submucosal P = 0·034
**
versus before P = 0·002
***
versus before P = 0·002
****
versus submucosal P = 0·052
Controls: Non-significant differences
†
The counts of cell types before not shown.