Table 1.
Fibronectin (FN) production by cultured human monocytes stimulated with lipopolysaccharide (LPS) or cytokines
| FN concentration (ng/ml) at | |||
|---|---|---|---|
| Stimulation with | 4 h | 24 h | |
| None | 267·3 ± 55·6 | 444·8 ± 50·1 | |
| IL-1α | 2 U/ml | 378·3 ± 43·3 | 578·4 ± 98·7 |
| 20 U/ml | 595·0 ± 143·5 | 818·4 ± 103·6* | |
| 200 U/ml | 802·2 ± 160·3* | 1079·4 ± 157·2* | |
| IL-6 | 2 U/ml | 390·3 ± 51·9 | 601·0 ± 38·6 |
| 20 U/ml | 589·0 ± 63·3 | 766·8 ± 169·5* | |
| 200 U/ml | 791·3 ± 120·1* | 1159·2 ± 202·5* | |
| TNF-α | 2 U/ml | 378·0 ± 30·8 | 533·2 ± 71·8 |
| 20 U/ml | 749·0 ± 217·5 | 948·0 ± 207·9* | |
| 200 U/ml | 988·6 ± 176·1* | 1248·6 ± 143·6* | |
| LPS | 2 μg/ml | 393·0 ± 33·6 | 582·7 ± 63·2 |
| 20 μg/ml | 624·1 ± 72·0 | 869·2 ± 182·7* | |
| 200 μg/ml | 808·7 ± 23·6* | 1168·2 ± 204·3* | |
Monocytes were cultured with medium, IL-1α, IL-6, tumour necrosis factor-alpha (TNF-α) or LPS (2 mg/ml, 20 mg/ml, 200 mg/ml) for 4 h or 24 h. FN in culture supernatants was measured by radioimmunoassay. Mean ± s.d., n = 16
*
P <0·01.