Fig. 2.

FITC-labelled oligonucleotides were administered intracolonically in DSS colitis, and the time course of distribution of the antisense oligonucleotides was examined with confocal laser microscopy. (a) Three hours after administration, FITC signals were detected mainly in the colonic epithelium, although some signals were detected in the lamina propria; (b) 24 h after administration, FITC signals were observed predominantly in the lamina propria.