Table 1.

Mortality of B6 mice following vaccination and Mycobacterium tuberculosis H37Rv challenge

	MST ± s.e.m. (days)
Group	A. 5 × 105 CFU/mouse	B. 2 × 105 CFU/mouse
1. Non-vaccinated control	24·8 ± 1·3	31·6 ± 2·9
2. M. bovis BCG-Prague	> 70	> 90
3. M. smegmatis::p16R1	25·1 ± 0·7	66·3 ± 4·7
4. M. smegmatis::p16R1-19	24·1 ± 0·7	42·9 ± 5·9*
5. M. smegmatis::cosmid 19-kD	29·5 ± 1·7	52·5 ± 3·2*
6. M. vaccae::p16R1	ND	57·8 ± 2·0
7. M. vaccae::p16R1-19	ND	46·6 ± 2·5*
8. VIJNS-Tpa	20·0 ± 0·72	ND
9. VIJNS-Tpa19	28·9 ± 2·61**	ND

^*Significant decrease in mean survival time (MST) compared with the corresponding vector control group.

^**Significantly different from the plasmid control group (P < 0·01 by Student's t-test).