1 |
69 |
F |
Sjögren's disease |
Necrotic and purpuric lesions on legs and feet |
4·6 |
4·6 |
5·6 |
IgMκ and IgG |
IgMκ and IgG |
No |
Prednisone |
Septic shock. Died |
2 |
62 |
F |
Scleroderma (CREST) |
Raynaud's phenomenon, skin necrotic ulcerations |
1·7 |
3·5 |
0·26 |
0 |
IgG, IgA and IgM |
No |
Prostacyclin, calcium blockers |
Recurrence skin lesions |
3 |
76 |
F |
Polymyositis. Pyocyanic infection |
Fever and muscle weakness |
2·8 |
4·6 |
0·01 |
IgMλ, IgG and IgA |
IgMλ, IgG and IgA |
No |
Prednisone |
Septic shock. Died |
4 |
57 |
F |
Polymyositis |
Muscle weakness |
0·32 |
2·9 |
0·06 |
IgM |
IgM |
No |
Prednisone |
Clinical remission |
5 |
34 |
M |
Systemic lupus erythematosus |
Kidney involvement of systemic lupus |
1·4 |
3·1 |
0·1 |
IgMλ |
IgMλ |
No |
Cyclophos- phamide, prednisone, aspirin |
Clinical remission |
6 |
45 |
F |
Lupus-like arthritis |
Arthralgia |
0·12 |
5 |
0·12 |
IgG, IgA and IgM |
IgG, IgA and IgM |
No |
Prednisone, cyclophos-phamide |
Clinical remission |
7 |
37 |
F |
Hashimoto hypothyroidism |
Perineal skin nodules |
3·4 |
3·7 |
0·09 |
IgG, IgA and IgM |
IgG, IgA and IgM |
No |
Coumadin, prednisone |
Clinical remission |
8 |
47 |
F |
Osteitis |
Livedo, ulcerations ofthe legs, gangrene |
3 |
4·6 |
0·08 |
IgG, IgA and IgM |
IgG, IgA and IgM |
No |
Coumadin Feet amputation |
ND |
9 |
50 |
M |
Erysipelas |
Swelling and ulcerations of the lower extremities |
1·3 |
3·6 |
0·01 |
IgGκ |
IgG, IgA and IgM |
No |
Antibiotics |
CF present only during febrile illness |
10 |
29 |
M |
CMV infection |
Weakness, fever, purpuric lesionsof the legs |
0·9 |
2·7 |
0·9 |
IgG, IgA and IgM |
IgG, IgA and IgM |
No |
Dressingchanges, wound care |
Recurrence during febrile illness |
11 |
47 |
M |
Hepatitis C. Vasculitis. Waldenström |
Painful ulcer of the legs. Myocardial infarction |
0·39 |
3·7 |
0·25 |
IgMκ, IgG and IgA |
IgMκ, IgG and IgA |
No |
– |
Died |
12 |
60 |
F |
Hepatitis C Arthralgia |
Purpura of the legs |
0·9 |
4·5 |
0·73 |
IgM |
IgM |
No |
IFN-α, ribavirin, plasma-pheresis |
Recurrence |
13 |
56 |
M |
Myeloprolifer- ative disease |
Mucosal lesions |
0·5 |
5·4 |
0·12 |
0 |
IgG |
No |
Chemo- therapy. IFN-α |
Died |
14 |
80 |
M |
Factor XII deficiency |
Painful ulcers of the legs Extradural haematoma |
1·28 |
5 |
0·03 |
IgG, IgA and IgM |
IgG, IgA and IgM |
No |
Vasodilators |
Recurrence of skin lesions |
15 |
50 |
M |
Severe atherosclerosis. Idiopathic? |
Non-healing ulcerations on the legs. Alcoholism |
2 |
4·6 |
0·07 |
IgG, IgA and IgM |
IgG, IgA and IgM |
Yes |
Occlusive dressing |
ND |
16 |
35 |
M |
Idiopathic |
Skin necrotic ulcerations, Raynaud's phenomenon, gangrene |
0·49 |
8·6 |
0·07 |
IgMλ |
IgMλ, IgG and IgA |
No |
Cyclophos-phamide, prednisone,coumadin |
Recurrence of skin lesions |
17 |
48 |
F |
Idiopathic |
Recurrent pulmonary embolisms. Renal veinthrombosis |
1·2 |
3·5 |
|
IgMλ |
IgMλ, IgG and IgA |
No |
Heparine, coumadin |
Clinical remission |
18 |
52 |
M |
Idiopathic |
Stroke |
0·47 |
5·25 |
0·02 |
0 |
IgMλ, IgG and IgA |
Yes |
Coumadin |
Pain of legs and feet |
19 |
35 |
M |
Idiopathic |
Purpuric lesions, pulmonary fibrosis |
3·36 |
7·3 |
0·01 |
0 |
0 |
No |
Prednisone |
Purpura |