Table 7.
Levels of soluble thrombomodulin (sTM), chemokines, selectins, and platelet activation markers before and after ticlopidine treatment in diabetic patients with elevated sTM levels
| Before | After | P | |
|---|---|---|---|
| sTM (TU/ml) | 13·1 ± 1·9 | 9·5 ± 2·3 | < 0·01 |
| IL-8 (pg/ml) | 10·3 ± 1·5 | 10·1 ± 1·7 | NS |
| MCP-1 (pg/ml) | 398 ± 22 | 275 ± 31 | < 0·01 |
| RANTES (ng/ml) | 124 ± 11 | 86 ± 9 | < 0·01 |
| sP-selectin (ng/ml) | 245 ± 29 | 144 ± 23 | < 0·001 |
| sE-selectin (ng/ml) | 70·3 ± 6·1 | 45·9 ± 5·3 | < 0·01 |
| plt:P-selectin (%) | 11·2 ± 1·5 | 4·5 ± 2·1 | < 0·01 |
| plt:Annexin V (%) | 11·3 ± 1·7 | 8·6 ± 1·8 | < 0·05 |
| PMP (/104 plt) | 693 ± 75 | 420 ± 63 | < 0·05 |
Values are the means ± s.e.m. (n = 8).
NS, Not significant; MCP-1, monocyte chemotactic peptide 1; RANTES, regulated on activation normally T-cell expressed and secreted; plt:P-selectin, P-selectin-positive platelets; plt:Annexin V, annexin V binding to platelets; PMP, platelet-derived microparticles.
TU, Teijin unit.