Fig. 4.

Pachymetry in treated and control corneal allograft recipients, demonstrating effect of TNFR-Ig on graft survival. Corneal allograft function was assessed by pachymetry, increase in thickness correlating with observed onset of endothelial rejection. Solid lines show rabbits which received five intracameral injections, each of 0·1 mg of TNFR-Ig on alternate days 8–16 following corneal transplantation (n = 7); early post-grafting thickness did not correlate with graft survival. Broken lines show pachymetry on allograft controls treated with 0·1 mg human IgG1 on days 8–16 post-transplantation (n = 3). The data are highly suggestive of a protective effect of the TNFR-Ig injections, but do not reach statistical significance (Mann–Whitney U-test, P = 0·06).