Fig. 1.

Lymphadenopathy and splenomegaly in CD4^slpr^cg (□), CD4^mlpr^cg (▪), and CD4^s/mlpr^cg (hatched) groups. External lymph nodes (LN) (a), internal LN (b), mesenteric LN (c) and spleen (d) weights were determined at 3 months old in 10 males and 10 females in the first two groups, and at 5 months old in 11 males and 11 females in all groups, and the results are presented as mean ±s.e.m. Significant difference compared with sex- and age-matched CD4^slpr^cg mice at *P < 0·05, **P <0·01, and ***P <0·001, by t-test.