Fig. 2.

Renal histopathology (a) and glomerular immune deposits (b) in CD4^slpr^cg (s), CD4^mlpr^cg (m), and CD4^s/mlpr^cg (s/m) groups. The severity of glomerulonephritis at 3 and 5 months old, and the extent of immune deposition detected with anti-C3 antibody at 5 months old were scored on a 0–3 scale as described in Materials and methods. Open and solid circles represent single male and female mice, respectively. Significant difference between the two groups at *P < 0·05, **P <0·01, and ***P <0·001, by t-test.