Table 1.
The serial change in the level of cytokines in the aqueous lung extract*
| Days | TNF-α | IL-1β | IFN-γ | IL-2 | IL-4 | IL-5 |
|---|---|---|---|---|---|---|
| Before inoculation | 17·5 ± 5·7 | 6·5 ± 1·7 | ND | ND | ND | ND |
| 7 | 1274·0 ± 157·2** | 1929·7 ± 649·8** | 35·2 ± 19·4** | 35·0 ± 23·6** | 75·2 ± 16·5** | 19·7 ± 4·3** |
| 30 | 1117·0 ± 218·9** | 2382·8 ± 724·1** | 30·2 ± 8·8** | 40·0 ± 22·8** | 80·3 ± 11·9** | 27·4 ± 9·1** |
| 60 | 1393·5 ± 325·3** | 2041·8 ± 547·3** | 120·8 ± 30·1** | 91·2 ± 10·6** | 63·5 ± 13·4** | 23·0 ± 11·2** |
*
Values expressed as mean ±s.d.
Each group consisted of four animals; ND, not detectable.
**
P < 0·01 versus before inoculation.
The experiments were reproducible (n = 3).