Fig. 4.

Time course to determine optimal time of migration of ¹¹¹In-huPBL into synovial grafts. ¹¹¹In-huPBL (10 × 10⁶) were injected intravenously into synovium-transplanted SCID mice which had received intragraft injections of either 200 ng TNF-α (▪) or saline (□). At various time points mice were killed and the grafts extracted and radioactivity levels determined by γ counter. Migration is expressed as percentage of injected dose (ID)/wt (g). n = 6 transplants/condition; mean ±s.e.m.; P = 0·007.