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. 2000 Oct;122(1):101–108. doi: 10.1046/j.1365-2249.2000.01351.x

Fig. 4.

Fig. 4

Enhanced immunogenicity of a cocktail mixture of peptide conjugates. Mice were immunized with a physical mixture of the pCST3–heterospecies dimer (HSD), pMTB–HSD and pRSV–HSD conjugates adsorbed on alum. Three injections each containing an equimolar mixture of conjugates (5 μg each) were given intramuscularly at an interval of 4 weeks. Groups of mice were also immunized with HSD alone or diphtheria toxoid (DT)–HSD. Antibody titres at 5 and 9 weeks are shown in individual sera as points with bar as geometric mean of the group. Mean peak titres with peptide mixture is significantly higher (P < 0·05) than corresponding DT–HSD groups of all strains except SJL.