Changes in serum IL-18 levels in three patients with primary biliary cirrhosis. Serum IL-18 levels elevated with the increase of serum bilirubin in two out of three cases. However, the level in case 1 elevated approximately one and half years prior to the increase of serum bilirubin. LRLT, Living-related liver transplantation (✦, IL-18; ▪, total bilirubin; •, ALP).